"It's not about how to achieve your dreams. It's about how to lead your life. If you lead your life the RIGHT WAY, the karma (destiny, fortune, good luck) will take care of itself. The dreams will come to you."
               Dr. Randy Pausch 

He is saying that believe that anything can happen, if you believe it won't happen then it might not happen or it will come true. Also that if you dream of something you want to do then do it. He is also telling us not to give up on what we want to do. Lastly, he is saying is to CTR.